Text S3.dvi
نویسندگان
چکیده
We here report a statistical fact in support of the basic assumption underlying our model. The matching condition we employ dictates a certain correlation between the sets of regulated genes by each TF: if the binding sequence of a TF (A) is embedded in that of a TF (B), then the set of genes {Gi}B regulated by TFB in our model is a subset of {Gi}A. A similar investigation of the yeast databases listed below reveals that the top 50% of the TF pairs related by the sequence inclusion relation above, rank in the top 3% when all the TF pairs are listed according to the overlap of their {Gi} sets. The actual ranking of the TF pairs obtained among all possible pairs of 102 TFs with known binding sequences is shown in Fig. 1.
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